The U.N. and other aid agencies scrambled to step up relief as Israel and Hamas began a four-day truce.
Medical facilities are running out of supplies and fuel, which Israel hasn't allowed into Gaza for a month now.
In one glimmer of hope, hundreds of people were allowed to enter Egypt from Gaza, which one U.N. official called a "graveyard" for children who are caught up in the fighting.
Humanitarian aid trickled into Gaza but agencies were being forced to scale back as fuel and other basic items were depleted and diplomats remained at an impasse.
While Israel pounded Gaza with increasingly intensifying airstrikes in response to Hamas' surprise attacks, the U.N. chief emphasized the rules of war must be obeyed.
Despite some aid trickling into Gaza through Egypt's Rafah crossing, needs are soaring as tensions flare that could cause the Israel-Hamas war to spread to other countries.
Aid groups call for humanitarian corridor and respect for rules of war as Israel-Hamas war escalates
Officials say civilians' basic needs and protections must be upheld in accord with international humanitarian law.
The fighting that broke out last month caused the ranks of those who need humanitarian aid and protection to swell to 24.6 million, or slightly more than half of Sudan's 49 million.
Sudan's unraveling forced humanitarian aid organizations, including those with staff killed by fighting, to suspend operations, despite millions of civilians in great need.
Most of the employees who work for the U.N. Assistance Mission in Afghanistan are Afghan nationals, women and men, who have been told to stay home because of the ban.
"The tragic reality is that an effective response was hampered in part by challenges that relate directly to the unresolved issues at the heart of the conflict," the U.N. special envoy to Syria, Geir Pedersen, told the U.N. Security Council.
The U.N. emergency relief coordinator's office set a US$4.3 billion target to help people suffering in the war-torn nation.
As Putin's war in Ukraine nears the one-year mark with no end in sight, the U.N. again calls on the international community to step up with billions more in aid for civilians and refugees.
The death toll from the magnitude 7.8 and 7.5 earthquakes that hit Turkey and northern Syria a week ago rose to more than 36,000 people as the search continued for loved ones trapped in the rubble despite a closing survival window.
Fresh snowfall, freezing temperatures and a disrupted cross-border operation between southern Turkey and war-torn northern Syria added to the despair, frustration and anger.
While many developing nations suffered droughts and floods — from Pakistan to the Horn of Africa — Russia’s invasion of Ukraine disrupted food supply lines and turned a large swath of Europe into a battlefield.